Colorectal cancer
Preclinical colorectal cancer models for in vivo studies of primary tumor progression, metastatic spread and therapeutic response.
Preclinical colorectal cancer model overview
Our colorectal cancer models provide an in vivo platform for studying primary tumor progression and metastatic spread to distant organs, including the liver and lungs. Longitudinal assessment of disease progression and therapeutic response supports evaluation of drug activity and PK/PD throughout preclinical studies.
Our orthotopic colorectal cancer model is established by transplanting cancer cells directly into the colon, enabling primary tumor growth and metastatic progression to be studied within the relevant anatomical environment. Longitudinal monitoring allows tumor development, metastatic spread and therapeutic response to be followed throughout the study.
In addition to tumor transplantation models, IVRS offers models of chronic intestinal inflammation to investigate inflammation-driven colorectal cancer development. These models enable the progression from chronic inflammation to tumor formation to be studied in vivo and provide a platform for evaluating therapeutic interventions at different stages of disease development.
Key capabilities
- Primary colorectal tumor progression
- Liver & lung metastasis monitoring
- Longitudinal treatment response
- Drug activity & PK/PD read-outs
Segment models
Explore our cancer models
Pancreatic cancer
Orthotopic pancreatic cancer models support high-resolution monitoring of tumor progression, metastasis, and treatment response.
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Breast cancer
Our orthotopic breast cancer model provides a clinically relevant platform for studying primary tumor growth, metastatic spread, and therapeutic response.
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Glioblastoma
Our orthotopic glioblastoma (GBM) model provides a clinically relevant platform for evaluating tumor growth, invasion, and therapeutic response.
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Lung cancer
Our orthotopic lung cancer model provides a clinically relevant platform for studying tumor growth, metastatic spread, and therapeutic response.
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Ovarian cancer
Ovarian cancer models include orthotopic and disseminated systems reflecting primary tumor growth and peritoneal metastasis.
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Leukemia
Leukemia models recapitulate systemic disease and bone marrow interactions, enabling sensitive tracking of progression and treatment response.
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Renal cell carcinoma
Renal cell carcinoma models reflect the vascularized and metastatic nature of kidney tumors.
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Colorectal cancer
Colorectal cancer models replicate tumor growth in the colon and spread to distant organs such as the liver and lungs.
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