Glioblastoma
Preclinical orthotopic glioblastoma (GBM) models for in vivo studies of brain tumor growth, progression and therapeutic response.3. Scientific overview heading
Preclinical glioblastoma model overview
Our orthotopic glioblastoma (GBM) model provides an in vivo platform for studying brain tumor growth, progression and therapeutic response. Longitudinal bioluminescence imaging (BLI), combined with 3D imaging and CT, enables quantitative monitoring and anatomical localization of GBM progression over time.
Our orthotopic glioblastoma model uses patient-derived or cell line-derived GBM cells implanted stereotactically into the mouse striatum, establishing tumors within the relevant brain microenvironment. Longitudinal bioluminescence imaging (BLI) enables quantitative, non-invasive monitoring of tumor burden and progression in the same animal over time.
BLI can be combined with 3D imaging and CT to provide anatomical localization of the intracranial tumor. Near-infrared fluorescent probes can also be incorporated to investigate tumor-associated processes including angiogenesis, apoptosis, metabolism and hypoxia. Studies can be complemented by behavioral assessment, blood or CSF sampling, histology and molecular analyses to further characterize disease progression and therapeutic response.
Key capabilities
- Stereotactic orthotopic GBM implantation
- PDX, CDX & allograft models
- Longitudinal BLI + 3D CT imaging
- Tumor biology & behavioral read-outs
Segment models
Explore our cancer models
Pancreatic cancer
Orthotopic pancreatic cancer models support high-resolution monitoring of tumor progression, metastasis, and treatment response.
Explore model →
Breast cancer
Our orthotopic breast cancer model provides a clinically relevant platform for studying primary tumor growth, metastatic spread, and therapeutic response.
Explore model →
Glioblastoma
Our orthotopic glioblastoma (GBM) model provides a clinically relevant platform for evaluating tumor growth, invasion, and therapeutic response.
Explore model →
Lung cancer
Our orthotopic lung cancer model provides a clinically relevant platform for studying tumor growth, metastatic spread, and therapeutic response.
Explore model →
Ovarian cancer
Ovarian cancer models include orthotopic and disseminated systems reflecting primary tumor growth and peritoneal metastasis.
Explore model →
Leukemia
Leukemia models recapitulate systemic disease and bone marrow interactions, enabling sensitive tracking of progression and treatment response.
Explore model →
Renal cell carcinoma
Renal cell carcinoma models reflect the vascularized and metastatic nature of kidney tumors.
Explore model →
Colorectal cancer
Colorectal cancer models replicate tumor growth in the colon and spread to distant organs such as the liver and lungs.
Explore model →
Let us to contribute
to your growth
Do you want to learn more about our work and how we can help you?