Leukemia
Preclinical leukemia models for in vivo studies of systemic disease progression, organ infiltration and therapeutic response.
Preclinical leukemia model overview
Our preclinical leukemia models provide an in vivo platform for studying systemic disease progression, organ infiltration and therapeutic response. Longitudinal monitoring enables quantitative assessment of leukemia burden and distribution over time, supporting evaluation of drug activity, PK/PD and treatment durability.
Our in vivo leukemia models enable transplantation of acute or chronic leukemia cells of myeloid or lymphoid origin to establish systemic disease in animals. Longitudinal monitoring allows leukemia progression and the distribution of malignant cells across different organs to be followed over time.
Quantitative imaging and complementary biological read-outs can be used to assess leukemia burden and organ infiltration throughout disease progression and treatment. This provides a flexible platform for evaluating therapeutic response across different leukemia subtypes and stages of disease.
Key capabilities
- Acute & chronic leukemia models
- Myeloid & lymphoid leukemia
- Systemic progression & organ infiltration
- Longitudinal treatment monitoring
Segment models
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Breast cancer
Our orthotopic breast cancer model provides a clinically relevant platform for studying primary tumor growth, metastatic spread, and therapeutic response.
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Glioblastoma
Our orthotopic glioblastoma (GBM) model provides a clinically relevant platform for evaluating tumor growth, invasion, and therapeutic response.
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Lung cancer
Our orthotopic lung cancer model provides a clinically relevant platform for studying tumor growth, metastatic spread, and therapeutic response.
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Ovarian cancer
Ovarian cancer models include orthotopic and disseminated systems reflecting primary tumor growth and peritoneal metastasis.
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Leukemia
Leukemia models recapitulate systemic disease and bone marrow interactions, enabling sensitive tracking of progression and treatment response.
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Renal cell carcinoma
Renal cell carcinoma models reflect the vascularized and metastatic nature of kidney tumors.
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Colorectal cancer
Colorectal cancer models replicate tumor growth in the colon and spread to distant organs such as the liver and lungs.
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