Lung cancer

Preclinical orthotopic lung cancer models for in vivo studies of NSCLC tumor growth, metastatic progression and therapeutic response.

Preclinical lung cancer model overview

Our orthotopic NSCLC model provides a clinically relevant platform for studying lung tumor growth, metastatic progression and therapeutic response in vivo. Longitudinal bioluminescence imaging (BLI) combined with CT enables sensitive monitoring and spatial localization of tumor progression over time.

Non-small cell lung cancer (NSCLC) is the most common form of lung cancer and remains a major therapeutic challenge. Our orthotopic NSCLC mouse model uses intratracheal instillation of human or syngeneic luciferase- expressing lung cancer cells to establish tumors directly within the lung.

Longitudinal in vivo bioluminescence imaging enables tumor growth and metastatic progression to be monitored from the first week after inoculation. Combining BLI with CT provides anatomical localization of lung tumors and assessment of tumor progression. Near-infrared fluorescent probes can also be incorporated to investigate angiogenesis, apoptosis, metabolism, hypoxia and other tumor-associated biological processes.

Key capabilities