Pancreatic cancer
Preclinical orthotopic pancreatic cancer models for in vivo studies of primary tumor growth, metastatic progression and therapeutic response.
Scientific overview
Our orthotopic pancreatic cancer model provides a clinically relevant platform for studying primary tumor growth, metastatic progression and therapeutic response in vivo. Longitudinal bioluminescence imaging (BLI), combined with 3D imaging and CT, enables quantitative monitoring and spatial localization of pancreatic tumor progression and metastatic spread.
Our orthotopic pancreatic cancer mouse model uses patient-derived or cell line-derived xenografts expressing luciferase, implanted directly into the pancreas to establish primary tumors in vivo. Longitudinal bioluminescence imaging (BLI) enables quantitative monitoring of primary tumor growth and metastatic progression in the same animal over time.
BLI can be combined with 3D imaging and CT to spatially localize pancreatic tumors and metastatic sites. Near-infrared fluorescent probes can also be incorporated to investigate tumor-associated processes including angiogenesis, apoptosis, metabolism and hypoxia. Studies can be complemented by blood sampling, histology and molecular analyses for further characterization of treatment effects.
Key capabilities
- Orthotopic pancreatic implantation
- PDX & cell-line xenograft models
- Longitudinal BLI + CT imaging
- Primary tumor & metastasis monitoring
Segment models
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Ovarian cancer
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Renal cell carcinoma
Renal cell carcinoma models reflect the vascularized and metastatic nature of kidney tumors.
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Colorectal cancer
Colorectal cancer models replicate tumor growth in the colon and spread to distant organs such as the liver and lungs.
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